I work in computer support at a large university. I support several hundred PCs, about 100 Macs, and a couple dozen Linux boxes.
Unix & Linux
Q&A for users of Linux, FreeBSD and other Un*x-like operating systems.
Physical Fitness
Q&A for physical fitness professionals, athletes, trainers, and those providing health-related needs
Motor Vehicle Maintenance & Repair
Q&A for mechanics and DIY enthusiast owners of cars, trucks, and motorcycles
Programmers
Q&A for professional programmers interested in conceptual questions about software development
TeX - LaTeX
Q&A for users of TeX, LaTeX, ConTeXt, and related typesetting systems
Android Enthusiasts
Q&A for enthusiasts and power users of the Android operating system
Meta Stack Overflow
Q&A for meta-discussion of the Stack Exchange family of Q&A websites
Physics
Q&A for active researchers, academics and students of physics
Board & Card Games
Q&A for people who like playing board games, designing board games or modifying the rules of existing board games
Cryptography
Q&A for software developers, mathematicians and others interested in cryptography
Biology
Q&A for biology researchers, academics, and students
Ask Different
Q&A for power users of Apple hardware and software